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【2020 Solutions】 Rui Ai Biotech Pioneers Global Home-based Smart Occult Blood Testing for Early Colorectal Cancer Detection

On average, one person is diagnosed with colorectal cancer every 37 minutes, making it the most prevalent type of cancer in the country for many years. In its early stages, the disease is almost asymptomatic, and if there is lower gastrointestinal bleeding, it often goes unnoticed when mixed with feces. Patients without regular screening habits can easily miss the optimal treatment window. Unlike the existing iFOBT stool tests, Rui Ai Biotech has developed the world's first home-use 'Hemoglobin Sensor' (referred to as 'Blood Gun'), which can detect blood in the toilet bowl after defecation. This helps users to interpret risks that are invisible to the naked eye, aiming not just to facilitate home health management, but also to improve the screening willingness and initiative of potential patients.

Patent King's Startup, Home-use Blood Gun Wins National Innovation Award

The current hospital-based fecal occult blood test requires individuals to collect stool samples and go to the hospital for biochemical analysis. This process lacks convenience and immediacy, reducing the public's willingness to undergo testing. When the blood in a patient's stool solution is visible to the naked eye, it often indicates that the disease has progressed to stage II or III.

In light of this, the innovative research team from Hsinchu, Rui Ai Biotech, founded in 2017 by Dr. Yan Shuo-Ting, a renowned 'Patent King' from Foxconn group, identified a gap in the current needs for occult blood testing. Utilizing his expertise in semiconductor optics and proprietary algorithms, he led the team to develop the 'Hemoglobin Sensor' for home use, which not only attracted angel investments from the US but also garnered numerous patents and the 16th National Innovation Award in 2019, winning countless accolades nationally and internationally.

Photometric Occult Blood Sensing Technology: A 10-second Test After Toilet Use

The Hemoglobin Sensor is easy to use. Employing optical sensing technology, users simply follow five steps after defecation to effectively detect early signs and initiate early treatment.

● Step One: After defecation, allow the feces to settle in the water for five minutes, then attach the specialized filter paper to the front probe of the sensor

● Step Two: Press and hold the power button for three seconds to turn on the device

● Step Three: Briefly press the sensing button to begin measurement, immerse the front probe in water for about 10-15 seconds

● Step Four: After viewing the results displayed on the screen, push the filter paper into the water (the paper is biodegradable) and flush confidently

● Step Five: Rinse the probe with clean water for 3-5 seconds and wipe with a tissue, place it back on the charging stand

Blood Gun Usage Method (Image Source: Rui Ai Biotech)

▲ Blood Gun Usage Method (Image Source: Rui Ai Biotech)

Optics Combined with AI Improves Accuracy, Creating a Staple Home Product

The main challenge in home-based occult blood testing is eliminating noise, identifying hemoglobin signals, and analyzing them. There are currently home-based hemoglobin test papers available; however, due to the difficulty in avoiding impurities at home which affects accuracy, and the relatively high cost of consumables, it has not yet become widespread in the market. The photometric 'Hemoglobin Sensor' breaches these technological barriers, with its internal optical components utilizing a highly sensitive CMOS image sensor (CIS), combined with an optical module minimized to the smallest possible size. The proprietary algorithm analyzes and effectively avoids noise interference, accurately determining the results as negative (no occult blood) or positive (occult blood present).

Blood Gun Spectral Sensing Technology Diagram (Image Source: Rui Ai Biotech)

▲ Blood Gun Spectral Sensing Technology Diagram (Image Source: Rui Ai Biotech)

The handheld 'Hemoglobin Sensor' has been crowdfunding on the platform ZecZec since February this year, reaching its target of one million New Taiwan dollars by the end of March. It is also available for purchase on PChome Store Street (https://www.pcstore.com.tw/redeye/). Rui Ai Biotech hopes to make the Hemoglobin Sensor a household essential for testing, and is also committed to promoting the extended application of this patented technology, such as integrating it into smart toilets. The product has already attracted attention from several domestic and international bathroom and health testing equipment manufacturers, presenting considerable potential business opportunities and marketability.

Rui Ai Biotech Team, fourth from the left is CEO Dr. Yan Shuo-Ting (Image Source: Rui Ai Biotech Facebook)

▲ Rui Ai Biotech Team, fourth from the left is CEO Dr. Yan Shuo-Ting (Image Source: Rui Ai Biotech Facebook)

Rui Ai Biotech Blood Gun Introduction (Image Source: Rui Ai Biotech)

▲ Rui Ai Biotech Blood Gun Introduction (Image Source: Rui Ai Biotech)

(This article is published with permission from Rui Ai Biotech on AI HUB)

「Translated content is generated by ChatGPT and is for reference only. Translation date:2024-05-19」

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【解決方案】客廳化身為健身房 Uniigym矢志成為健身界的Netflix
Living Room as a Gym: Uniigym Aims to be the Netflix of Fitness

Afflicted by the pandemic, most people choose to stay at home However, for those who enjoy exercising, missing a day at the gym can feel uncomfortable With Uniigym's 'AR Fitness x Uniigym' app, users have access to nearly 1,000 diverse exercise classes With a dedicated AI coach, users can exercise anytime they wish, while also tracking their fitness journey, and understanding their condition completely To encourage public fitness and fight the pandemic together, Uniigym has also collaborated with Chunghwa Telecom, offering free access to the 'AR Fitness x Uniigym' app for 30 days starting from now until the end of June, contributing to the public health effort Founded in 2019 by CEO Yu-Chieh Lin, Uniigym was conceived from the monotony and limited options of gym venues like fitness centers and school gyms, and low interaction with trainers The company aims to make exercising as fun as gaming through technological solutions, starting with their first product—an intelligent dynamic 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【解決方案】7毫秒內分離人聲 洞見未來科技協助聽損者「聽說更簡單」
Voice Separation in 7 Milliseconds: RelaJet's Future Technology Makes 'Hearing and Speaking Easier' for the Hearing Impaired

One rainy Thursday afternoon near Taipei Arena, the Taipei Experience Center of RelaJet was fully booked with appointments from people with hearing loss eager to try hearing aids made with a voice separation engine For the hearing impaired, having affordable, lightweight, and effective noise-reducing hearing aids is truly a blessing 'We hope to help users in need to hear the world's wonders again' This empathetic expectation by RelaJet's founder and CEO Po-Ju Chen, who is also hearing impaired, illustrates his understanding of the needs of the hearing impaired He hopes that RelaJet's unique voice amplification hearing aid technology will benefit many more people Affordable hearing aids benefit many with hearing loss Founded in 2018 by Po-Ju Chen and his brother Yu-Ren Chen, RelaJet developed a multi-voice separation engine paired with Qualcomm's Bluetooth audio platform, drastically reducing the price of imported hearing aids, typically costing 80,000-100,000 NT dollars, to just under 10,000 NT dollars They aim to develop affordable goods with excellent noise-cancelling capabilities that wirelessly connect to smartphones In its first two years, the company primarily developed the multi-voice separation engine, which significantly improved the noise reduction quality Once equipped with Qualcomm Bluetooth earphone chips, the audio processing time is drastically short, at about 7 milliseconds to enhance main voice projection and reduce ambient noise, less than half the time required by traditional medical standard of 16 milliseconds for hearing aids, nearly 'zero-delay' 洞見未來科技推出平價助輔聽器,大大嘉惠聽損者 Yu-Ren Chen explains that the primary use of Qualcomm chips for edge computing, along with a streamlined algorithm, achieves extremely low latency and better noise reduction The hearing aids can cover 18 channels, whereas traditional hearing aids cover 4-48 channels In the future, RelaJet will progressively increase the number of channels According to statistics, there are 470 million people globally with hearing disabilities, with a 30 average device use rate in developed countries, with the highest in Western countries Taiwan has nearly 15 million people with disabling hearing loss, of which the middle-aged and elderly make up 30, yet the device use rate is only about 10, which is quite low Yu-Ren Chen further analyzes that the low device usage rate is due to two reasons firstly, the high average selling price of international big brands ranges from 80,000 to 200,000 NT dollars with a three-year usability period, which deters many due to the high cost and maintenance Secondly, in noisy environments, the noise is also amplified which does not necessarily ensure clarity for the users, and the sound parameters can't be adjusted in real-time, making it inconvenient to frequently visit stores for tuning Thirdly, most models cannot connect to smartphones, making it inconvenient for the hearing impaired to take phone calls Utilizing Qualcomm Bluetooth chips for rapid product development In light of this, Po-Ju Chen, formerly a semiconductor engineer at MediaTek, leads the technical development, while Yu-Ren Chen, with a legal background, manages the operations Their seamless collaboration, along with their team employing AI algorithms and chip integration, learns from thousands of hours of audio files in databases through neural networks and deep learning technologies to develop low-latency, high-noise-reduction voice amplification technologies for hearing aids In 2019, this sound processing technology was integrated into Qualcomm Bluetooth chips, winning first place in the Qualcomm Taiwan Startup Competition and becoming a partner in Qualcomm's Global Expansion Program, significantly boosting product development pace In 2021, they launched their own Otoadd series of hearingenhancement products in Taiwan, which received both market favor and positive reviews from many with hearing loss Based on different consumer needs, various product 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【解決方案】破壞式創新商模 奇翼醫電推出行動醫療裝置- 心電圖傳感器 打造遠距醫療當中最後一塊拼圖
Disruptive innovative business model Qiyi Medical Electronics launches mobile medical device-ECG sensor to create the last piece of the puzzle in telemedicine

With the advent of the post-epidemic era, the development of global telemedicine is in the ascendant, which has greatly increased the demand for smart medical technology in decentralized medicine Among them, if mobile medical devices can provide real-world at home or outside the hospital data for use in hospitals, it is believed that it will reduce the burden of diagnosis and treatment on doctors or medical personnel and reduce health insurance expenses To this end, Singular Wings Medical has launched a comprehensive telemedicine solution, which combines excellent wearable mobile medical device design, innovative software development, AI algorithms and cloud platform services, and will become the last piece of telemedicine puzzle David Lee, the founder and general manager of Qiyi Medical Electronics, said that his original intention to start the business was because he witnessed Taiwan's long-term pursuit of low-cost mass production, which led to the continuous decline in the value of the industry For example, in the past thirty years, The output value of the former Silicon Valley was similar to that of Taiwan's Hsinchu Science Park, but thirty years later, the output value of Silicon Valley reached US14 trillion at the end of 2020, while the output value of Hsinchu Science Park was less than NT15 trillion at the end of 2021 Seeing Silicon Valley's sensitivity to industry needs and disruptive innovations such as Uber, Airbnb, industry trends and the post-epidemic era have driven a surge in telemedicine services, thereby creating high industry value, so I started a business at the age of 45 and conceived how to combine it with Taiwan After more than ten years of accumulated industrial advantages and Silicon Valley's innovative model, we decided to help Taiwan's industry upgrade and find a new path through the integration of the medical industry, ICT technology industry and innovative business models Seeing that Taiwan has always been a gathering place for the most elite talents in the medical industry and electronics and electrical industry, I believe that through the combination of the two and innovative business models, we can have the opportunity to follow Silicon Valley and create a different business According to Taiwan’s Communication Diagnosis and Treatment Methods, Taiwan’s market demand for telemedicine is divided into two situations emergency such as COVID-19 and special necessity such as special geographical locations such as outlying islands or mountains It is allowed Carry out communication medical diagnosis In fact, the development of global telemedicine decentralized medicine is in the ascendant, but the demand for smart medical technology to meet decentralized medicine still needs to be realized In addition to the medical technology gap, it also includes medical treatment flow, patient identification, remote Remote consultation and collection are fueling the push for smart medical technology Li Weizhong observed that for telemedicine decentralized medicine to be successfully implemented, it is best to use telemedicine devices that are used outside the hospital or at home and are easily available in daily life Among them, the data of the device is the key It can provide doctors with out-of-hospital real-world data Real World Data or Real World Evidence that they can trust and apply, so that they can improve their diagnosis and treatment methods In fact, this type of telemedicine device is not popular, making remote medical care difficult to complete In addition, as the number of wearable devices such as bracelets and watches increases, most of the data that these devices can truly provide is insufficient for medical purposes and is not easy to validate and verify Li Weizhong said that people are paying more and more attention to health awareness, which is a positive encouragement for telemedicine devices He believes that as long as there is an appropriate business model and the right way to cooperate with hospitals and doctors can reduce the burden on doctors or medical personnel and reduce health insurance expenditures, Qi Yi Medical Electronics will definitely have the opportunity to become the last piece of the puzzle in telemedicine Founded in 2015, Qiyi Medical Electronics’ core team consists of 22 diversified professionals, including young engineers with medical, engineering and information backgrounds and experienced entrepreneurs, working together to create an overall solution for remote healthcare The solution includes hardware design, software development and backend cloud platform services for the mobile medical device Beatinfor Health electrocardiogram sensor Electrocardiogram ECG is one of the most important vital signs body temperature, pulse, respiration and physiological data of the human body, which can reflect various physiological changes in the human body, such as cardiovascular health, inflammation, infection, bleeding, injury or anxiety index changes For this core concept, Qiyi Medical is committed to using wearable electrocardiograms as its core technology, while collecting important vital signs and environmental parameters such as electrocardiograms, and building AI algorithm systems and backend cloud platform services based on big data and machine learning to help solve remote problems Specific chronic diseases such as cardiovascular disease, sleep problems, and metabolic diseases are the most important in medical treatment Electrocardiogram sensor continuous physiological data monitoring reduces the risk of death in acute heart failure patients by 11 within 30 days after discharge In order to realize remote medical services, Qiyi Medical Electronics has launched a complete set of remote medical care solutions, including wearable mobile medical devices-electrocardiogram sensor BEATINFO ECG, BEATINFO HEALTH APP, and AI algorithms , web pages and BEATINFO HEALTH cloud service platform The BEATINFO ECG sensor is an exclusive device for the 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Cardiovascular assessment reports, third-party remote medical consultation services and other functions Users use patch-type or chest-strap ECG sensors paired with end-to-cloud platforms for continuous physiological detection Before being transmitted to the cloud for further calculations, all data will be de-identified and made available to professionals Data reports are provided for physician judgment The BEATINFO HEALTH cloud service platform has powerful noise filtering processing capabilities, fast waveform recognition and judgment, as well as highly complex cloud architecture and communication technology Why is the noise filter processing capability so important Because medical equipment in general hospitals must require users to complete short-term measurements under static conditions Usually, data in life situations outside the hospital cannot be collected by the hospital, and this data is very important to doctors It is increasingly important to understand the progression of the disease and the condition of patients leaving the hospital Therefore, if we continue to record very weak ECG signals in daily life, we actually need to overcome a very high technical threshold After these signals are processed by the noise, they will first be judged by the AI algorithm before preliminary and rapid conclusions can be made Users can instantly avoid certain fatal risks The cloud architecture provides a deeper level of second-order computing and also covers the business model architecture It provides service models such as user management, automatic report generation, record keeping, alarm notifications, and connection with more services such as third-party alarms Emergency rescue, third-party medical consultation, doctor and patient docking, medical treatment cash flow and other functions In terms of competitive advantages in the industry, compared with the industry's braceletwatch products, Qiyi Medical's electrocardiogram sensor BEATINFO ECG provides accurate medical-level measurements, and can continuously record and collect physiological data, improving any Sudden or sporadic symptoms may occur Compared with the electrocardiogram patch of its peers, it provides real-time data return and web-based management tools, and can produce various reports for managers to remotely manage a large number of users on the web According to statistics from Beijing Medical University, the mortality rate of patients with acute heart failure within 30 days after discharge is as high as 11 If an electrocardiogram sensor is installed on the patient for continuous and real-time monitoring for 30 days, it is possible to reduce part of the risk of death, and at the same time, it can Significantly reduce health insurance costs Additionally, in the case of cardiovascular disease, if the user wears the device for a period of time, regular cardiovascular assessment reports can be obtained and provided for follow-up in-depth examinations by doctors In addition to the measurement of cardiovascular diseases, the ECG sensor configuration can provide home assessment of sleep apnea OSA During the measurement, patients can discover potential and easily overlooked cardiovascular diseases, and users do not need to stay in the sleep ward for treatment After a boring night, through the ECG sensor patch and AI algorithm, patients only need to sleep at home for one night to receive an OSA test report If needed, doctors can access patient status remotely and instantly via any internet browser Therefore, through the ECG sensor wearable service, users can discover hidden and unknown cardiovascular diseases such as arrhythmias related to sudden death from the measurement process to avoid unnecessary regrets Qiyi Medical Electronics’ business model is mainly B2B2C, hoping to assist individuals, hospitals, enterprises, care services and other units to create a win-win situation Li Weizhong analyzed that the business cooperation model is quite flexible, whether it is leasing or buying out wearable measurement devices, or providing annual report subscriptions to reduce the cost of purchasing devices for users, such as including 2-minute electrocardiogram, Flexible subscription package including 7-day cardiovascular health assessment, exercise cardiovascular health assessment, sleep health assessment report, etc Group cardiovascular monitoring system solution creates a many-to-many real-time physiological information monitoring platform to replace diagnosis with prevention In addition to providing individual users with remote mobile physiological data measurement, the BEATINFO cloud platform provides a "group cardiovascular monitoring system" solution that can create many-to-many real-time physiological information monitoring through network technology Based on the platform, patients only need to wear a lightweight monitoring patch, and the back-end system can grasp the changes in their physiological information, so that prevention can replace diagnosis and reduce the chance of sudden cardiovascular death This platform provides 3 functions, including the ability to manage different users into groups and hierarchically, and the number of users can reach tens of thousands it can display users’ basic physiological information in real time on web tools, and can be used under certain preset conditions When triggered, this platform will immediately send out an alarm historical data can also be reviewed on the platform, which is very suitable for doctors to check the patient's disease progression outside the hospital during consultation For the application of the "Group Cardiovascular Monitoring System" solution, taking high-intensity exercise as an example, such as long-distance running and cycling, mountain climbing activities or traveling abroad, a prior cardiovascular health assessment is required activities, and corresponding evaluation reports This report allows users to share it with doctors, so that participants can make assessments before the event or test their training effectiveness, which can significantly reduce the risk of accidents during the event beforehand During the activity, the group cardiovascular monitoring system also provides real-time on-site monitoring of a large number of participants It can be monitored in real time by the AI in the background at the moment of exercise Once an accident occurs, the platform can immediately issue an alarm and even report the accident GPS positioning of the location, and continuously transmits back the user's physiological information during search and rescue, striving for golden rescue time In sports monitoring applications, taking golf as an example, how to improve golfers' puttinghitting performance A player's performance and concentration are usually directly related to personal emotional stability Li Weizhong said that through HRV analysis of Qiyi Medical's electrocardiogram device, it can help determine the player's emotional and stress index performance, and at the same time help golf coaches select and train players The group cardiovascular monitoring system can create a many-to-many real-time physiological information monitoring platform Establish a firm foothold in Taiwan, move towards the US and European markets, and move towards the goal of a data company Faced with the challenges of technology research and development and market promotion, Qiyi Medical Electronics’ automatic identification of electrocardiograms requires a large amount of data for AI calculation development For this reason, Qiyi Medical Electronics must cooperate with hospitals and develop jointly Finish At present, the company has established good cooperative relations with many medical centers and research units, and has overcome these technical bottlenecks one by one In terms of market promotion, Li Weizhong said that the biggest challenge facing Qiyi Medical Electronics is to communicate with the market and let the public understand the differences between competitors' bracelet and watch products and the company's mobile device-electrocardiogram sensor Compared with the common bracelet and watch products on the market that collect electrocardiogram data in a discontinuous manner, it may take a long time to collect discontinuous data before potential cardiovascular problems can be discovered by luck Qiyi Medical Electronics actively promotes electrocardiogram to the public in a continuous manner The competitive functional characteristics of sexual detection data and emphasize that it is a very important means to assist in the detection of many potential diseases, replacing diagnosis with prevention and reducing the occurrence of unnecessary cardiovascular diseases In addition, in terms of business promotion, we also hope to create more opportunities for business matching and new venture capital raising with the assistance of the Corporate Resource Strategy Council Looking to the future, Li Wei and Xu Qiyi Medical Electric Energy will become the last piece of the telemedicine puzzle in the health wearable device-electrocardiogram service Li Weizhong said that in the short term, Qiyi Medical hopes to gain a firm foothold in Taiwan and become a common medical device in everyone's home, just like thermometers and blood pressure monitors The company is also constantly developing new indications Starting from electrocardiogram, coupled with AI and big data, it can deal with more chronic diseases In addition to cardiovascular diseases, we have also successively developed sleep apnea and other more special diseases The applications are aimed at the problems of elderly chronic diseases that modern people are very likely to encounter With a mid- to long-term plan, Qiyi Medical will enter the US and EU markets, become an international company, and continue to aim to become a data company, making good use of the company's long-term collection of data applications to provide services in diverse fields such as new drug development and vaccine development application to create business opportunities and profits 「Translated content is generated by ChatGPT and is for reference only Translation date:2024-05-19」